While misanthropy has been analyzed taking into account one country and just comparing results, we employ the 2004 International Social Survey Program data set and assess its determinants from a cross-country analysis by considering personal characteristics and country effects. Findings indicate that misanthropy is explained by sociodemographic and economic characteristics (being a woman, education, and marriage reduce misanthropy while being young or poor, and self-employment have the opposite effect). Country effects result significant consequently, some environmental factors play a relevant role. Finally, we add new elements to the discussion by showing a strong relationship among our misanthropy ranking and two corruption perception rankings.