The Relation Between Response to Hypotonic Stress and the 51Cr Recovery In Vivo of Preserved Platelets

Authors

  • C. R. Valeri,

    1. Naval Blood Research Laboratory, Chelsea, Massachusetts
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    • 2

      C. R. Valeri, CAPT, MC, USNR, Officer in Charge, Naval Blood Research Laboratory, Chelsea, Mass.

  • H. Feingold,

    1. Naval Blood Research Laboratory, Chelsea, Massachusetts
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    • 3

      H. Feingold, Medical Technologist, Naval Blood Research Laboratory, Chelsea, Mass.

  • L. D. Marchionni

    1. Naval Blood Research Laboratory, Chelsea, Massachusetts
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    • 4

      L. D. Machionni, Research Technician, Naval Blood Research Laboratory, Chelsea, Mass.


Abstract

Platelet response to hypotonic stress can be used to estimate the 51Cr recovery in vivo of liquid- and freeze-preserved platelets. This simple in vitro test may prove helpful in determining and controlling the quality of preserved platelets. In our study, the response to hypotonic stress was not related to the 51Cr T-1/2 value of the preserved platelets, but was related to the number of irreversibly damaged platelets removed within two hours after transfusion.

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