Supported by the NHLBI Contracts N01-HB-97077 (superseded by N01-HB-47114), N01-HB-97079, N01-HB-97080, N01-HB-97081, and N01-HB-97082.
ABO and Rh(D) phenotype frequencies of different racial/ ethnic groups in the United States
Article first published online: 26 APR 2004
Volume 44, Issue 5, pages 703–706, May 2004
How to Cite
Garratty, G., Glynn, S. A., McEntire, R. and Retrovirus Epidemiology Donor Study (2004), ABO and Rh(D) phenotype frequencies of different racial/ ethnic groups in the United States. Transfusion, 44: 703–706. doi: 10.1111/j.1537-2995.2004.03338.x
- Issue published online: 26 APR 2004
- Article first published online: 26 APR 2004
- Received for publication October 15, 2003; revision received January 7, 2004, and accepted January 8, 2004.
BACKGROUND: Commonly quoted ABO/Rh(D) frequencies in the US are usually from relatively small studies with racial or ethnic categories often judged by name or appearance.
STUDY DESIGN AND METHODS: A 10-year demo-graphic database that contained racial or ethnic and ABO/Rh(D) phenotype data on 3.1 million allogeneic and autologous donors giving blood at five blood centers in the US was used to compute ABO and Rh(D) phenotypes in various racial/ethnic groups. The racial or ethnic category was designated by the donor.
RESULTS: The highest percentage of Group O was found in Hispanic (56.5%), North American Indian (54.6%), and black non-Hispanic (50.2%) donors. Hispanic and black non-Hispanic donors had a much lower percentage (7.3 and 7.1%, respectively) of Rh– compared to white non-Hispanic donors (17.3%). Group O Rh– and Group B Rh– were found more commonly (8.0 and 1.8%, respectively) in white non-Hispanic donors than in Hispanic (3.9 and 0.7%), black non-Hispanic (3.6 and 1.3%), and Asian (0.7 and 0.4%) donors.
CONCLUSIONS: These data confirmed that the highest percentages of ORh+, BRh+/ABRh+, and Rh– are present in Hispanic, Asian, and white non-Hispanic donors, respectively. These are the largest and most accurate data of ABO/Rh(D) phenotype frequencies for the major racial/ethnic donor groups in the US.