The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study

Authors

  • Laura Mazzucco,

    1. 1From the Department of Haematology & Blood Transfusion Medicine; the Department of Surgery, Division of Cardiac Surgery, Unit of Plastic and Reconstructive Surgery; and the Department of Pathology and Clinical Oncology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
    Search for more papers by this author
  • Dante Medici,

    1. 1From the Department of Haematology & Blood Transfusion Medicine; the Department of Surgery, Division of Cardiac Surgery, Unit of Plastic and Reconstructive Surgery; and the Department of Pathology and Clinical Oncology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
    Search for more papers by this author
  • Massimo Serra,

    1. 1From the Department of Haematology & Blood Transfusion Medicine; the Department of Surgery, Division of Cardiac Surgery, Unit of Plastic and Reconstructive Surgery; and the Department of Pathology and Clinical Oncology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
    Search for more papers by this author
  • Renzo Panizza,

    1. 1From the Department of Haematology & Blood Transfusion Medicine; the Department of Surgery, Division of Cardiac Surgery, Unit of Plastic and Reconstructive Surgery; and the Department of Pathology and Clinical Oncology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
    Search for more papers by this author
  • Giorgio Rivara,

    1. 1From the Department of Haematology & Blood Transfusion Medicine; the Department of Surgery, Division of Cardiac Surgery, Unit of Plastic and Reconstructive Surgery; and the Department of Pathology and Clinical Oncology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
    Search for more papers by this author
  • Sara Orecchia,

    1. 1From the Department of Haematology & Blood Transfusion Medicine; the Department of Surgery, Division of Cardiac Surgery, Unit of Plastic and Reconstructive Surgery; and the Department of Pathology and Clinical Oncology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
    Search for more papers by this author
  • Roberta Libener,

    1. 1From the Department of Haematology & Blood Transfusion Medicine; the Department of Surgery, Division of Cardiac Surgery, Unit of Plastic and Reconstructive Surgery; and the Department of Pathology and Clinical Oncology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
    Search for more papers by this author
  • Elena Cattana,

    1. 1From the Department of Haematology & Blood Transfusion Medicine; the Department of Surgery, Division of Cardiac Surgery, Unit of Plastic and Reconstructive Surgery; and the Department of Pathology and Clinical Oncology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
    Search for more papers by this author
  • Alessandro Levis,

    1. 1From the Department of Haematology & Blood Transfusion Medicine; the Department of Surgery, Division of Cardiac Surgery, Unit of Plastic and Reconstructive Surgery; and the Department of Pathology and Clinical Oncology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
    Search for more papers by this author
  • Pier Giacomo Betta,

    1. 1From the Department of Haematology & Blood Transfusion Medicine; the Department of Surgery, Division of Cardiac Surgery, Unit of Plastic and Reconstructive Surgery; and the Department of Pathology and Clinical Oncology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
    Search for more papers by this author
  • Piero Borzini

    Corresponding author
    1. 1From the Department of Haematology & Blood Transfusion Medicine; the Department of Surgery, Division of Cardiac Surgery, Unit of Plastic and Reconstructive Surgery; and the Department of Pathology and Clinical Oncology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
      Piero Borzini, MD, Director Servizio Medicina Trasfusionale, Ospedale SS Antonio e Biagio, Via Venezia 16, 15100 Alessandria AL, Italy; e-mail: pborzini@ospedale.al.it.
    Search for more papers by this author

  • TRANSFUSION 2004;44:1013-1018.

Piero Borzini, MD, Director Servizio Medicina Trasfusionale, Ospedale SS Antonio e Biagio, Via Venezia 16, 15100 Alessandria AL, Italy; e-mail: pborzini@ospedale.al.it.

Abstract

BACKGROUND:  Chronic ulcers can benefit from topical treatment with growth factors (GFs). PLT gel provides tissue regeneration-inducing GFs. The aim of this study was to verify the effectiveness of autologous PLT gel in the treatment of nonhealing skin lesions.

STUDY DESIGN AND METHODS:  PLT gel was pro-duced by treating PLTs with autologous thrombin. Two groups of patients were investigated: patients with dehis-cent sternal wounds and patients with necrotic skin ulcers. Patients treated with PLT gel were retrospectively compared with patients having similar lesions but undergoing conventional treatment. The clinical endpoints of the study were the healing rate, the length of hospital stay, and/or the time required to bring about adequate tissue regeneration in order to undergo reconstructive plastic surgery.

RESULTS:  In patients with treated dehiscent sternal wounds the healing rate (3.5 vs. 6.0 wks, p = 0.0002) and hospital stay (31.5 vs. 52.5 days, p < 0.0001) were signi-ficantly reduced. Patients with treated necrotic skin ulcers required a notably shorter time to have surgery (median 15.0 vs. 35.5 wks, p < 0.0001). Neither adverse reactions nor in-situ recurrences were observed.

CONCLUSIONS:  Patients with chronic unhealing wounds showed substantial improvement when treated with PLT gel lesion dressings.

Ancillary