This study was funded by the National Heart, Lung, and Blood Institute of the U.S. National Institutes of Health (N01-HB-47174). The creation of the SCANDAT database was funded by the National Heart, Lung, and Blood Institute and the National Cancer Institute of the U.S. National Institutes of Health (N01-CP-21175). GE has received funding through a postdoctoral stipend from Svenska Sällskapet för Medicinsk Forskning (SSMF). MKJ and HH have received funding from the Danish Medical Research Council (271-08-0831). ELM has received a career development award (K24-HL-75036) from the U.S. National Heart, Lung, and Blood Institute. The funding organization did not participate in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Duration of red blood cell storage and survival of transfused patients (CME)
Article first published online: 12 FEB 2010
© 2010 American Association of Blood Banks
Volume 50, Issue 6, pages 1185–1195, June 2010
How to Cite
Edgren, G., Kamper-Jørgensen, M., Eloranta, S., Rostgaard, K., Custer, B., Ullum, H., Murphy, E. L., Busch, M. P., Reilly, M., Melbye, M., Hjalgrim, H. and Nyrén, A. O. (2010), Duration of red blood cell storage and survival of transfused patients (CME). Transfusion, 50: 1185–1195. doi: 10.1111/j.1537-2995.2010.02583.x
- Issue published online: 1 JUN 2010
- Article first published online: 12 FEB 2010
- Received for publication October 15, 2009; revision received November 11, 2009, and accepted December 1, 2009.
Vol. 50, Issue 8, 1857, Article first published online: 2 AUG 2010
BACKGROUND: Disquieting reports of increased complication and death rates after transfusions of red blood cells (RBCs) stored for more than 14 days prompted us to perform an observational retrospective cohort study of mortality in relation to storage time.
STUDY DESIGN AND METHODS: We conducted a cohort study utilizing data on all recipients of at least one RBC transfusion in Sweden and Denmark between 1995 and 2002, as recorded in the Scandinavian Donations and Transfusions (SCANDAT) database. Relative risks of death in relation to storage time were estimated using Cox regression, adjusted for several possible confounding factors.
RESULTS: After various exclusions, 404,959 transfusion episodes remained for analysis. The 7-day risk of death was similar in all exposure groups, but a tendency for a higher risk emerged among recipients of blood stored for 30 to 42 days (hazard ratio, 1.05; 95% confidence interval [CI], 0.97-1.12), compared to recipients of blood stored for 10 to 19 days. With 2-year follow-up, this excess remained at the same level (hazard ratio, 1.05; 95% CI, 1.02-1.08). No dose-response pattern was revealed and no differential effect was seen when the analyses were restricted to recipients of leukoreduced units only.
CONCLUSION: Although a small excess mortality was noted in recipients of the oldest RBCs, the risk pattern was more consistent with weak confounding than with an effect of the momentary exposure to stored RBCs. It seems, thus, that any excess mortality conferred by older RBCs in the combined Swedish and Danish transfusion recipient population is likely less than 5%, which is considerably smaller than in the hitherto largest investigation.