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A systematic assessment of the quality of reporting for platelet transfusion studies

Authors

  • Meghan Delaney,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Erin Meyer,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Christine Cserti-Gazdewich,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Richard L. Haspel,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Yulia Lin,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Anna Morris,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Katerina Pavenski,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Walter H. Dzik,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Mike Murphy,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Sherrill Slichter,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Grace Wang,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Larry J. Dumont,

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Nancy Heddle

    1. From the Puget Sound Blood Center, Seattle, Washington; the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; the University Health Network/University of Toronto, Toronto, Ontario, Canada; the Beth Israel Deaconess Medical Center, Boston, Massachusetts; the Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; NHS Blood and Transplant Filton, Bristol, UK; St Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; NHS Blood and Transplant, Oxford Radcliffe Hospitals and University of Oxford, UK; and McMaster University, Hamilton, Ontario, Canada.
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  • Support: On behalf of the BEST Collaborative.

Meghan Delaney, Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104, e-mail: meghand@psbc.org.

Abstract

BACKGROUND: As evidence-based medicine assumes increasing importance, there is a need for high-quality reporting of clinical studies. A recent review of clinical platelet (PLT) studies indicated variability in reporting. We undertook a critical analysis of PLT transfusion studies to determine the quality of reporting.

STUDY DESIGN AND METHODS: A systematic MEDLINE search for clinical studies of PLT transfusion was performed to identify articles. Relevant observational studies (OBS) were critiqued using the STROBE checklist and randomized controlled clinical trials (RCTs) using the CONSORT checklist. Studies were further evaluated with a PLT-specific checklist developed by the authors. Observations were analyzed descriptively and using Pareto analysis.

RESULTS: A total of 772 articles were identified by the search. Eighty-six articles (23 RCTs and 63 OBS) met eligibility criteria. All RCTs, and a similar number of OBS (24), were randomly selected for analysis. Studies reported the scientific background and rationale, key results, and outcomes. OBS frequently did not consider bias and confounders. RCTs frequently did not explain bias, interim analyses, stopping rules, success of blinding, or weaknesses of multiple analyses. The PLT-specific critique found many studies adequately reported basics of the PLT product, PLT increment, and transfusion reactions. Studies frequently failed to report specific details of PLT compatibility, details of product preparation, and use of other blood products.

CONCLUSION: Recently published articles of clinical PLT transfusion share common strengths and weaknesses. The quality of reporting may be improved by providing guidelines to authors and journal editors that list the essential elements of a well-reported clinical study of PLT transfusion.

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