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ABO hemolytic disease of the fetus and newborn: an iatrogenic complication of heterologous assisted reproductive technology-induced pregnancy

Authors

  • Antonio Alberto Zuppa,

    1. From the Department of Pediatrics, Division of Neonatology, and the Immunohematology Laboratory,Transfusion Centre, Catholic University of Sacred Heart, Rome, Italy.
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  • Valentina Cardiello,

    1. From the Department of Pediatrics, Division of Neonatology, and the Immunohematology Laboratory,Transfusion Centre, Catholic University of Sacred Heart, Rome, Italy.
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  • Marco Lai,

    1. From the Department of Pediatrics, Division of Neonatology, and the Immunohematology Laboratory,Transfusion Centre, Catholic University of Sacred Heart, Rome, Italy.
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  • Luigi Cataldi,

    1. From the Department of Pediatrics, Division of Neonatology, and the Immunohematology Laboratory,Transfusion Centre, Catholic University of Sacred Heart, Rome, Italy.
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  • Vito D'Andrea,

    1. From the Department of Pediatrics, Division of Neonatology, and the Immunohematology Laboratory,Transfusion Centre, Catholic University of Sacred Heart, Rome, Italy.
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  • Costantino Romagnoli

    1. From the Department of Pediatrics, Division of Neonatology, and the Immunohematology Laboratory,Transfusion Centre, Catholic University of Sacred Heart, Rome, Italy.
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Prof. Antonio Alberto Zuppa, Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Hearth, Largo Agostino Gemelli 8, 00168 Rome, Italy; e-mail: zuppaaa@rm.unicatt.it.

Abstract

BACKGROUND: ABO hemolytic disease of the fetus and newborn (ABO HDFN) may manifest itself in cases of mothers belonging to blood group O and newborns of groups A or B and more frequently in group A and less so in group B.

CASE STUDY: The case subjects are twin-birth newborns with ABO HDFN, of group AB born to a mother of group O. These cases of ABO HDFN prove inconsistent with Mendel's law of segregation.

RESULTS AND CONCLUSION: This case study finds its explanation in new methods of assisted reproduction, particularly heterologous in vitro fertilization with ovodonation.

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