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Anaphylactic shock to fresh-frozen plasma inactivated with methylene blue
Article first published online: 27 JUL 2010
DOI: 10.1111/j.1537-2995.2010.02800.x
© 2010 American Association of Blood Banks
Additional Information
How to Cite
Nubret, K., Delhoume, M., Orsel, I., Laudy, J. S., Sellami, M. and Nathan, N. (2011), Anaphylactic shock to fresh-frozen plasma inactivated with methylene blue. Transfusion, 51: 125–128. doi: 10.1111/j.1537-2995.2010.02800.x
Publication History
- Issue published online: 10 JAN 2011
- Article first published online: 27 JUL 2010
- Received for publication February 2, 2010; revision received May 14, 2010, and accepted May 17, 2010.
- Abstract
- Article
- References
- Cited By
BACKGROUND: Methylene blue allergy is a well-known entity associated with food or lymph node location. Inactivation of viruses by methylene blue in fresh-frozen plasma (FFP-MB) has been recently introduced in France after many years of use in other parts of Europe.
CASE REPORT: We describe here two anaphylactic shock reactions occurring during FFP-MB infusion in patients after cardiac surgery. The follow-up was favorable using epinephrine infusion in one patient and extracorporeal circulatory assistance in the other.
RESULTS: The allergy was suspected based on the following arguments: chronology of the event, absence of other allergen infused to patients, and an associated symptom (generalized rash). Methylene blue allergy was documented by prick tests and/or intradermal reactions with methylene blue and patent blue. Additional allergic tests with basophil activation tests confirm the role of the dye in the anaphylactic reaction.
CONCLUSION: These two cases questioned the safety of FFP-MB.