Microparticles in stored red blood cells as potential mediators of transfusion complications

Authors

  • Wenche Jy,

    1. From the Wallace H. Coulter Platelet Laboratory, Division of Hematology and Oncology, Department of Medicine; the Division of Cardiothoracic Surgery, Department of Surgery; the Department of Pathology; and the Department of Epidemiology & Public Health, University of Miami School of Medicine, Miami, Florida.
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  • Marco Ricci,

    1. From the Wallace H. Coulter Platelet Laboratory, Division of Hematology and Oncology, Department of Medicine; the Division of Cardiothoracic Surgery, Department of Surgery; the Department of Pathology; and the Department of Epidemiology & Public Health, University of Miami School of Medicine, Miami, Florida.
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  • Sherry Shariatmadar,

    1. From the Wallace H. Coulter Platelet Laboratory, Division of Hematology and Oncology, Department of Medicine; the Division of Cardiothoracic Surgery, Department of Surgery; the Department of Pathology; and the Department of Epidemiology & Public Health, University of Miami School of Medicine, Miami, Florida.
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  • Orlando Gomez-Marin,

    1. From the Wallace H. Coulter Platelet Laboratory, Division of Hematology and Oncology, Department of Medicine; the Division of Cardiothoracic Surgery, Department of Surgery; the Department of Pathology; and the Department of Epidemiology & Public Health, University of Miami School of Medicine, Miami, Florida.
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  • Lawrence H. Horstman,

    1. From the Wallace H. Coulter Platelet Laboratory, Division of Hematology and Oncology, Department of Medicine; the Division of Cardiothoracic Surgery, Department of Surgery; the Department of Pathology; and the Department of Epidemiology & Public Health, University of Miami School of Medicine, Miami, Florida.
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  • Yeon S. Ahn

    1. From the Wallace H. Coulter Platelet Laboratory, Division of Hematology and Oncology, Department of Medicine; the Division of Cardiothoracic Surgery, Department of Surgery; the Department of Pathology; and the Department of Epidemiology & Public Health, University of Miami School of Medicine, Miami, Florida.
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  • This work was supported by grants from the Wallace H. Coulter Foundation and a grant from the National Institutes of Health (1R01HL098031).

Wenche Jy, PhD, Wallace H. Coulter Platelet Laboratory, Division of Hematology & Oncology, Department of Medicine, University of Miami School of Medicine, 1600 NW 10th Avenue, R-36A, Miami, FL 33176; e-mail: wjy@med.miami.edu.

Abstract

This article reviews evidence for the involvement of cell-derived microparticles (MPs) in transfusion-related adverse events. The controversy concerning possible added risk of older versus fresher stored blood is also reviewed and is consistent with the hypothesis that MPs are involved with adverse events. Although all types of circulating MPs are discussed, the emphasis is on red blood cell–derived MPs (RMPs). The evidence is particularly strong for involvement of RMPs in transfusion-related acute lung injury, but also for postoperative thrombosis. However, this evidence is largely circumstantial. Work in progress to directly test the hypothesis is also briefly reviewed.

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