This work was supported by grants from the Wallace H. Coulter Foundation and a grant from the National Institutes of Health (1R01HL098031).
Microparticles in stored red blood cells as potential mediators of transfusion complications
Article first published online: 15 APR 2011
© 2011 American Association of Blood Banks
Volume 51, Issue 4, pages 886–893, April 2011
How to Cite
Jy, W., Ricci, M., Shariatmadar, S., Gomez-Marin, O., Horstman, L. H. and Ahn, Y. S. (2011), Microparticles in stored red blood cells as potential mediators of transfusion complications. Transfusion, 51: 886–893. doi: 10.1111/j.1537-2995.2011.03099.x
- Issue published online: 15 APR 2011
- Article first published online: 15 APR 2011
- Received for publication January 19, 2011; accepted January 24, 2011.
This article reviews evidence for the involvement of cell-derived microparticles (MPs) in transfusion-related adverse events. The controversy concerning possible added risk of older versus fresher stored blood is also reviewed and is consistent with the hypothesis that MPs are involved with adverse events. Although all types of circulating MPs are discussed, the emphasis is on red blood cell–derived MPs (RMPs). The evidence is particularly strong for involvement of RMPs in transfusion-related acute lung injury, but also for postoperative thrombosis. However, this evidence is largely circumstantial. Work in progress to directly test the hypothesis is also briefly reviewed.