This publication was supported in part by the CTSA Grant UL1 RR025750, KL2 RR025749, and TL1 RR025748 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and NIH roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessary represent the official view of the NCRR or NIH.
Race, ABO blood group, and venous thromboembolism risk: not black and white
Version of Record online: 27 APR 2012
© 2012 American Association of Blood Banks
Volume 53, Issue 1, pages 187–192, January 2013
How to Cite
Fang, C., Cohen, H. W. and Billett, H. H. (2013), Race, ABO blood group, and venous thromboembolism risk: not black and white. Transfusion, 53: 187–192. doi: 10.1111/j.1537-2995.2012.03665.x
- Issue online: 8 JAN 2013
- Version of Record online: 27 APR 2012
- Received for publication January 16, 2012; revision received March 1, 2012, and accepted March 7, 2012.
BACKGROUND: The rate of venous thromboembolism (VTE) has been reported to be higher in blacks compared to whites. Non-O blood groups have also been associated with a significantly higher VTE risk. Given that a higher proportion of blacks have O blood group, one might have expected that black individuals would have fewer VTEs.
STUDY DESIGN AND METHODS: In this study, we analyzed race, sex, age, ABO or Rh blood group, and VTE risk in 60,982 black and white patients admitted over a span of 10 years.
RESULTS: The overall occurrence of VTEs was 7.6%, higher in males (8.7% males vs. 7.2% females), higher in non-O blood groups (8.5% non-O vs. 6.9% O blood group), and increased with age (5.8% <65 years, 11.3% ≥65 years). No difference in VTE rate was noted with Rh antigen positivity. When stratified by age, VTE rate was consistently higher in blacks and non-O blood groups. No difference was detected among the various non-O blood groups. To assess the potential confounder of comorbidities, we stratified patients according to Charlson comorbidity score. In a subgroup of healthy patients with age-independent Charlson comorbidity scores of 0 (n = 28,387), blacks still had an increased VTE risk and this risk was still higher with increasing age and in those with non-O blood groups.
CONCLUSION: We conclude that black race and non-O blood groups have increased VTE risk when stratified for age and that associated comorbidities do not explain these differences.