Transfusion-transmitted anaplasmosis from leukoreduced red blood cells
Version of Record online: 7 MAY 2012
© 2012 American Association of Blood Banks
Volume 53, Issue 1, pages 181–186, January 2013
How to Cite
Alhumaidan, H., Westley, B., Esteva, C., Berardi, V., Young, C. and Sweeney, J. (2013), Transfusion-transmitted anaplasmosis from leukoreduced red blood cells. Transfusion, 53: 181–186. doi: 10.1111/j.1537-2995.2012.03685.x
- Issue online: 8 JAN 2013
- Version of Record online: 7 MAY 2012
- Received for publication January 27, 2012; revision received March 22, 2012, and accepted March 23, 2012.
BACKGROUND: Human granulocytic anaplasmosis (HGA) is a tick-borne rickettsial infectious disease. To date four cases of transfusion-transmitted anaplasmosis (TTA) have been described in the literature, and only one from leukoreduced red blood cells (RBCs).
CASE REPORT: A 64-year-old patient with acute gastrointestinal blood loss was admitted to the hospital and received 5 units of prestorage leukoreduced RBCs. He was stabilized and discharged. He developed headache, fever, and chills 2 days after discharge and was readmitted. On Day 5 of his second admission polymorphonuclear leukocytes containing morulae consistent with HGA were reported in the peripheral smear.
RESULTS: Samples from the recipient tested positive by polymerase chain reaction (PCR) for Anaplasma phagocytophilum, the causative agent of HGA and a segment from one of the five donors tested positive by both serology and PCR.
CONCLUSION: Leukoreduction theoretically reduces the risk of TTA but does not interdict all infections. TTA requires consideration in recipients of RBC transfusion with unexplained fever.