Editor's note: This analytical review by Robert M. Winslow, MD, is being published posthumously. The topic and content reflect Winslow's lifelong interest in oxygen delivery mechanisms and their physiologic consequences. The monograph benefitted from numerous discussions and review by Drs Franklin Bunn, Kim Vandergriff, Jack Levin, Marcos Intaglietta, Michele Samaja, and Abdu Alayash, among others. Although Winslow was best known to the transfusion medicine community for his work with hemoglobin-based oxygen carriers, his original work in several related areas and his conclusions regarding the physiologic control of oxygen delivery should be of great interest to the readers of TRANSFUSION. We anticipate that this review will be a major contribution to a complex literature and appropriately, considering Winslow's decades of contributions to this field, will constitute a worthy epitaph for his distinguished scientific career. Because Robert Winslow's untimely death precluded his usual meticulous attention to the final details and prevented any response to reviewers' suggested revisions, the final manuscript process was organized by Nancy J. Winslow, prepared for publication by Harvey G. Klein, and accepted for publication without revision.—Paul M. Ness, MD.
Oxygen: the poison is in the dose
Article first published online: 15 JUL 2012
© 2012 American Association of Blood Banks
Volume 53, Issue 2, pages 424–437, February 2013
How to Cite
Winslow, R. M. (2013), Oxygen: the poison is in the dose. Transfusion, 53: 424–437. doi: 10.1111/j.1537-2995.2012.03774.x
- Issue published online: 5 FEB 2013
- Article first published online: 15 JUL 2012
- Received for publication March 19, 2012; accepted April 18, 2012.
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