These authors contributed equally to this manuscript.
Results of lookback for Chagas disease since the inception of donor screening at New York Blood Center
Article first published online: 15 AUG 2012
© 2012 American Association of Blood Banks
Volume 53, Issue 5, pages 1083–1087, May 2013
How to Cite
Kessler, D. A., Shi, P. A., Avecilla, S. T. and Shaz, B. H. (2013), Results of lookback for Chagas disease since the inception of donor screening at New York Blood Center. Transfusion, 53: 1083–1087. doi: 10.1111/j.1537-2995.2012.03856.x
- Issue published online: 9 MAY 2013
- Article first published online: 15 AUG 2012
- Received for publication June 18, 2012; revision received July 13, 2012, and accepted July 13, 2012.
BACKGROUND: Chagas disease is a parasitic infection by Trypanosoma cruzi, typically transmitted via infected triatomine bug fecal contamination of bite sites. Other routes of infection include congenital, oral, organ transplantation, and blood product transmission.
STUDY DESIGN AND METHODS: From 2007 until 2011, New York Blood Center screened donations for the presence of T. cruzi antibodies using a Food and Drug Administration–approved test. Confirmatory testing was performed and recipients of units donated by confirmed-positive donors were investigated via lookback.
RESULTS: A total of 204 donors were T. cruzi antibody positive representing 0.019% of all donors during this time period (1,066,516 unique donors screened). Of the enzyme-linked immunosorbent assay–reactive donors, 77 were confirmed positive by radioimmunoprecipitation assay (0.007%). At least 154 units from 29 of the confirmed-positive donors had been transfused to 141 recipients. At the time of lookback, 48 of the 141 recipients were alive and seven underwent T. cruzi screening. Two recipients were found to be immunofluorescence assay (IFA) positive. Both IFA-positive recipients received a leukoreduced apheresis platelet unit (two separate donations) from the same confirmed positive donor, a 72-year-old immigrant from Argentina.
CONCLUSIONS: Lookback analysis was able to identify the first two cases of probable transfusion-transmitted T. cruzi infection since implementation of the national screening program, which increases the total number of reported cases in the United States to 8.