• 1
    Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698703.
  • 2
    Ceelie H, Bertina RM, Van Hylckama Vlieg A, Rosendaal FR, Vos HL. Polymorphisms in the prothrombin gene and their association with plasma prothrombin levels. Thromb Haemost 2001; 85: 106670.
  • 3
    Perez-Ceballos E, Corral J, Alberca I, Vaya A, Llamas P, Montes R, Gonzalez-Conejero R, Vicente V. Prothrombin A19911G and G20210A polymorphisms' role in thrombosis. Br J Haematol 2002; 118: 6104.
  • 4
    Wylenzek M, Geisen C, Stapenhorst L, Wielckens K, Klingler KR. A novel point mutation in the 3′ region of the prothrombin gene at position 20221 in a Lebanese/Syrian family. Thromb Haemost 2001; 85: 9434.
  • 5
    Meadows CA, Warner D, Page S, Lyon E. Detection of novel mutation using fluorescent hybridization probes and melting temparature analysis. J Mol Diagn 2002; 3: 195.
  • 6
    Warshawsky I, Hren C, Sercia L, Shadrach B, Deitcher SR, Newton E, Kottke-Marchant K. Detection of a novel point mutation of the prothrombin gene at position 20209. Diagn Mol Pathol 2002; 11: 1526.
  • 7
    Balim Z, Kosova B, Falzon K, Bezzina Wettinger S, Colak Y. Budd–Chiari syndrome in a patient heterozygous for the point mutation C20221T of the prothrombin gene. J Thromb Haemost 2003; 1: 8523.
  • 8
    Schrijver I, Lenzi TJ, Jones CD, Lay MJ, Druzin ML, Zehnder JL. Prothrombin gene variants in non-Caucasians with fetal loss and intrauterine growth retardation. J Mol Diagn 2003; 5: 2503.
  • 9
    Danckwardt S, Gehring NH, Neu-Yilik G, Hundsdoerfer P, Pforsich M, Frede U, Hentze MW, Kulozik AE. The prothrombin 3′ end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations. Blood 2004; 104: 42835.
  • 10
    Ceelie H, Spaargaren-van Riel CC, Bertina RM, Vos HL. G20210A is a functional mutation in the prothrombin gene; effect on protein levels and 3′-end formation. J Thromb Haemost 2004; 2: 11927.