• 1
    De Gaetano G. Historical overview of the role of platelets in hemostasis and thrombosis. Haematologica 2001; 86: 34956.
  • 2
    Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002; 324: 7186.
  • 3
    McKee SA, Sane DC, Deliargyris EN. Aspirin resistance in cardiovascular disease: a review of prevalence, mechanisms, and clinical significance. Thromb Haemost 2002; 8: 7115.
  • 4
    Pulcinelli FM, Pignatelli P, Celestini A, Riondino S, Gazzaniga PP, Violi F. Inhibition of platelet aggregation by aspirin progressively decreases in long-term treated patients. J Am Coll Cardiol 2004; 43: 97984.
  • 5
    Michelson ADCM, Eikelboom JW, Gurbel P, Kottke-Marchant K, Kuniki TJ, Pulcinelli FM, Cerletti C, Rao AK on behalf of the Platelet Physiology Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Aspirin resistance: position paper of the working group on aspirin resistance. J Thromb Haemost 2005; 3: 130911.
  • 6
    Weber AA, Przytulski B, Schanz A, Hohlfeld T, Schror K. Towards a definition of aspirin resistance: a typological approach. Platelets 2002; 13: 3740.
  • 7
    Violi F, Pignatelli P, Pulcinelli FM. Aspirin. J Thromb Haemost 2004; 2: 3389.
  • 8
    Eikelboom JW, Hirsh J, Weitz JI, Johnston M, Yi Q, Yusuf S. Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation 2002; 105: 16505.
  • 9
    Minuz P, Gaino S, Zuliani V, Tommasoli RM, Benati D, Ortolani R, Zancanaro C, Berton G, Lechi Santonastaso C. Functional role of p38 mitogen activated protein kinase in platelet activation induced by a thromboxane A2 analogue and by 8-iso-prostaglandin F2alpha. Thromb Haemost 2002; 87: 88898.
  • 10
    Di Minno G, Silver MJ, Murphy S. Monitoring the entry of new platelets into the circulation after ingestion of aspirin. Blood 1983; 61: 10815.
  • 11
    Evangelista P, Manarini S, Capone ML, Ricciotti E, Di Francesco L, Patrignani P. Recovery of thromboxane biosynthesis by aspirintreated platelets in vitro: a novel mechanism of aspirin resistance. Circulation 2004; 110: 2167.
  • 12
    Rocca B, Secchiero P, Ciabattoni G, Ranelletti FO, Catani L, Guidotti L, Melloni E, Maggiano N, Zauli G, Patrono C. Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets. Proc Natl Acad Sci USA 2002; 99: 76349.
  • 13
    Zimmermann N, Wenk A, Kim U, Kienzle P, Weber AA, Gams E, Sehrör K, Hohlfeld T. Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery. Circulation 2003; 108: 5427.