• 1
    Sadler JE, Mannucci PM, Berntorp E, Bochkov N, Boulyjenkov V, Ginsburg D, Meyer D, Peake I, Rodeghiero F, Srivastava A. Impact, diagnosis and treatment of von Willebrand disease. Thromb Haemost 2000; 84: 16074.
  • 2
    Rodeghiero F. von Willebrand disease: still an intriguing disorder in the era of molecular medicine. Haemophilia 2002; 8: 292300.
  • 3
    Rodeghiero F, Castaman G, Dini E. Epidemiological investigation of the prevalence of von Willebrand's disease. Blood 1987; 69: 4549.
  • 4
    Castaman G, Federici AB, Rodeghiero F, Mannucci PM. Von Willebrand's disease in the year 2003: towards the complete identification of gene defects for correct diagnosis and treatment. Haematologica 2003; 88: 94108.
  • 5
    Eikenboom JC. Willebrand disease type 3: clinical manifestations, pathophysiology and molecular biology. In: MichielsJJ, ed. von Willebrand Factor and von Willebrand disease. London: Bailliere, 2001: 365379.
  • 6
    Sadler J, Rodeghiero F. Provisional criteria for the diagnosis of VWD type 1; on behalf of the SSC Subcommittee on von Willebrand factor. J Thromb Haemost 2005; 3: 7757.
  • 7
    Rodeghiero F, Castaman G. Willebrand disease type I: definition, phenotypes, clinical and laboratory assessment. In: MichielsJJ, ed. von Willebrand Factor and von Willebrand disease. London: Bailliere, 2001: 321335.
  • 8
    Kunicki TJ, Federici AB, Salomon DR, Koziol JA, Head SR, Mondala TS, Chismar JD, Baronciani L, Canciani MT, Peake IR. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees. Blood 2004; 104: 235967.
  • 9
    Abildgaard CF, Suzuki Z, Harrison J, Jefcoat K, Zimmerman TS. Serial studies in von Willebrand's disease: variability versus ‘‘variants”. Blood 1980; 56: 7126.
  • 10
    Gill JC, Endres-Brooks J, Bauer PJ, Marks WJ, Montgomery RR. The effect of ABO blood group on the diagnosis of von Willebrand disease. Blood 1987; 69: 16915.
  • 11
    Mohlke KL, Ginsburg D. von Willebrand disease and quantitative variation in von Willebrand factor. J Lab Clin Med 1997; 130: 25261.
  • 12
    Levy G, Ginsburg D. Getting at the variable expressivity of von Willebrand disease. Thromb Haemost 2001; 86: 1448.
  • 13
    Sadler JE. Von Willebrand disease type 1: a diagnosis in search of a disease. Blood 2003; 101: 208993.
  • 14
    Castaman G, Eikenboom JC, Bertina RM, Rodeghiero F. Inconsistency of association between type 1 von Willebrand disease phenotype and genotype in families identified in an epidemiological investigation. Thromb Haemost 1999; 82: 106570.
  • 15
    Pepe M. The Statistical Evaluation of Medical Tests for Classification and Prediction. Oxford: Oxford University Press, 2003.
  • 16
    StataCorp. Stata Statistical Software: Release 8.0. College Station: Stata Corporation, 2003.
  • 17
    Breiman L, Friedman J, Olshen R, Stone C. Classification and Regression Trees. Pacific Grove: Wadsworth, 1984.
  • 18
    Silwer J. von Willebrand's disease in Sweden.. Acta Paediatr Scand Suppl 1973; 238: 1159.
  • 19
    Nosek-Cenkowska B, Cheang MS, Pizzi NJ, Israels ED, Gerrard JM. Bleeding/bruising symptomatology in children with and without bleeding disorders. Thromb Haemost 1991; 65: 23741.
  • 20
    Sramek A, Eikenboom JC, Briet E, Vandenbroucke JP, Rosendaal FR. Usefulness of patient interview in bleeding disorders. Arch Intern Med 1995; 155: 140915.
  • 21
    Eikenboom JC, Castaman G, Kamphuisen PW, Rosendaal FR, Bertina RM. The factor VIII/von Willebrand factor ratio discriminates between reduced synthesis and increased clearance of von Willebrand factor. Thromb Haemost 2002; 87: 2527.
  • 22
    Kouides PA, Phatak PD, Burkart P, Braggins C, Cox C, Bernstein Z, Belling L, Holmberg P, MacLaughlin W, Howard F. Gynaecological and obstetrical morbidity in women with type I von Willebrand disease: results of a patient survey. Haemophilia 2000; 6: 6438.
  • 23
    Gluud C, Gluud LL. Evidence based diagnostics. BMJ 2005; 330: 7246.