International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)


Steven A. Krilis, Department of Immunology, Allergy and Infectious Disease, St George Hospital, 2 South St, Kogarah, NSW 2217, Australia.
Tel.: +612 93502955; fax: +61293503981; e-mail:


Summary.  New clinical, laboratory and experimental insights, since the 1999 publication of the Sapporo preliminary classification criteria for antiphospholipid syndrome (APS), had been addressed at a workshop in Sydney, Australia, before the Eleventh International Congress on antiphospholipid antibodies. In this document, we appraise the existing evidence on clinical and laboratory features of APS addressed during the forum. Based on this, we propose amendments to the Sapporo criteria. We also provide definitions on features of APS that were not included in the updated criteria.