• Open Access

Preanalytical conditions that affect coagulation testing, including hormonal status and therapy


Margareta Blombäck, Department of Molecular Medicine and Surgery, Coagulation Research, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Tel.: +46 8 5177 4437; fax: +46 8 312438; e-mail: margareta.blomback@ki.se Full text available at http://www.med.unc.edu/isth


Preanalytical conditions, be they due to the individual's physiologic state or to exogenous factors, can affect coagulation factors, in either a transient or a persistent manner, and need to be considered in laboratory testing. These conditions include physical and mental stress, diurnal variation, hormone levels and posture at the time of blood drawing. While testing of these factors has not been exhaustive and some results are conflicting, guidelines for testing conditions can be given.