A guide to murine fibrinolytic factor structure, function, assays, and genetic alterations


  • This is the third of three review articles originating in the Subcommittee on Animal, Cellular and Molecular Models, Scientific and Standardization Committee, International Society on Thrombosis and Haemostasis.

Gerhard J. Johnson, Professor of Medicine, VA Medical Center and University of Minnesota, One Veterans Drive, Minneapolis, MN 55417, USA.
Tel.: +1 612 467 4135; fax: +1 612 725 2149; e-mail: johns337@umn.edu


Summary.  The components and functions of the murine fibrinolytic system are quite similar to those of humans. Because of these similarities and the adaptability of mice to genetic manipulation, murine fibrinolysis has been studied extensively. These studies have yielded important information regarding the function of the several components of fibrinolysis. This review presents information on the structure, function and assay of mouse fibrinolytic parameters and it discusses the results of the extensive studies of genetically modified mice. It is intended to be a convenient reference resource for investigators of fibrinolysis.