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Association between inherited thrombophilic abnormalities and central venous catheter thrombosis in patients with cancer: a meta-analysis

  1. F. DENTALI1,
  2. M. GIANNI1,
  3. G. AGNELLI2,
  4. W. AGENO1

Article first published online: 6 NOV 2007

DOI: 10.1111/j.1538-7836.2007.02823.x

Issue

Journal of Thrombosis and Haemostasis

Journal of Thrombosis and Haemostasis

Volume 6, Issue 1, pages 70–75, January 2008

Additional Information

How to Cite

DENTALI, F., GIANNI, M., AGNELLI, G. and AGENO, W. (2008), Association between inherited thrombophilic abnormalities and central venous catheter thrombosis in patients with cancer: a meta-analysis. Journal of Thrombosis and Haemostasis, 6: 70–75. doi: 10.1111/j.1538-7836.2007.02823.x

Author Information

  1. 1

    Department of Clinical Medicine, University of Insubria, Varese

  2. 2

    Division of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy

*Francesco Dentali, Department of Clinical Medicine, University of Insubria, Viale Borri 57, Varese, 21100, Italy. Tel.: +39 0332 278594; fax: +39 0332 278595; e-mail: fdentali@libero.it

Publication History

  1. Issue published online: 19 DEC 2007
  2. Article first published online: 6 NOV 2007
  3. Received 21 June 2007, accepted 29 October 2007

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Keywords:

  • cancer;
  • central venous catheter;
  • inherited thrombophilic;
  • venous thromboembolism

Summary. Background: The risk of deep vein thrombosis (DVT) is increased in cancer patients with central venous catheters (CVC). Factor (F)V Leiden and the G20210A prothrombin mutation (PTM) may play a role in causing catheter-related DVT in patients with cancer. However, information on the association between these thrombophilic abnormalities and CVC-related thrombosis are scarce.

Purpose: To assess the risk of CVC-related thrombosis associated with these two thrombophilic disorders.

Methods: MEDLINE and EMBASE databases (up to March 2007); reference lists of retrieved articles. Studies comparing the prevalence of prothrombotic abnormalities in cancer patients with CVC-related thrombosis and in a control group of cancer subjects with CVC without thrombosis. Two reviewers independently selected studies and extracted study characteristics, quality and outcomes. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each trial and pooled.

Results: Ten studies involving 1000 patients were included. The pooled OR for CVC-related thrombosis was 4.6 (95% CI: 2.6, 8.1) in patients with FV Leiden. The pooled OR for CVC-related thrombosis was 4.9 (95% CI: 1.7, 14.3) in patients with PTM. The estimated attributable risk of CVC-related thrombosis was 13.1% for FV Leiden and 4.5% for PTM.

Conclusion: Our meta-analysis suggests that the presence of FV Leiden and PTM is associated with CVC-related thrombosis.

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