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Genetics of venous thrombosis

  1. F. R. ROSENDAAL1,2,
  2. P. H. REITSMA2,3

Article first published online: 13 JUL 2009

DOI: 10.1111/j.1538-7836.2009.03394.x

Issue

Journal of Thrombosis and Haemostasis

Journal of Thrombosis and Haemostasis

Special Issue: State of the Art 2009

Volume 7, Issue Supplement s1, pages 301–304, July 2009

Additional Information

How to Cite

ROSENDAAL, F. R. and REITSMA, P. H. (2009), Genetics of venous thrombosis. Journal of Thrombosis and Haemostasis, 7: 301–304. doi: 10.1111/j.1538-7836.2009.03394.x

Author Information

  1. 1

    Clinical Epidemiology

  2. 2

    Thrombosis and Haemostasis

  3. 3

    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

*Frits R. Rosendaal, Department of Clinical Epidemiology, C7-P, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands. Tel.: +31 71 526 4037; fax: +31 71 5266994. E-mail: F.R.Rosendaal@LUMC.NL

Publication History

  1. Issue published online: 13 JUL 2009
  2. Article first published online: 13 JUL 2009

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Keywords:

  • epidemiology;
  • genetics;
  • risk factors;
  • thrombophilia;
  • venous thrombosis

Summary.  Venous thrombosis (deep vein thrombosis, pulmonary embolism) is a common and serious disorder, with genetic and acquired risk factors. The genetic risk factors can be subdivided in to those that are strong, moderate and weak. Strong risk factors are deficiencies of antithrombin, protein C and protein S. Moderately strong are factor V Leiden, prothrombin 20210A, non-O blood group and fibrinogen 10034T. There are many weak genetic risk factors, including fibrinogen, factor XIII and factor XI variants. Even for moderately strong risk factors (relative risks 2–5), the majority of carriers will never develop thrombosis.

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