Regulation of megakaryocyte maturation and platelet formation

Authors

  • D. BLUTEAU,

    1. INSERM, U790, 39 rue Camille Desmoulins, Villejuif
    2. Institut Gustave Roussy, 39 rue Camille Desmoulins, Villejuif
    3. Université Paris XI, 39 rue Camille Desmoulins, Villejuif, France
    Search for more papers by this author
  • L. LORDIER,

    1. INSERM, U790, 39 rue Camille Desmoulins, Villejuif
    2. Institut Gustave Roussy, 39 rue Camille Desmoulins, Villejuif
    3. Université Paris XI, 39 rue Camille Desmoulins, Villejuif, France
    Search for more papers by this author
  • A. DI STEFANO,

    1. INSERM, U790, 39 rue Camille Desmoulins, Villejuif
    2. Institut Gustave Roussy, 39 rue Camille Desmoulins, Villejuif
    3. Université Paris XI, 39 rue Camille Desmoulins, Villejuif, France
    Search for more papers by this author
  • Y. CHANG,

    1. INSERM, U790, 39 rue Camille Desmoulins, Villejuif
    2. Institut Gustave Roussy, 39 rue Camille Desmoulins, Villejuif
    3. Université Paris XI, 39 rue Camille Desmoulins, Villejuif, France
    Search for more papers by this author
  • H. RASLOVA,

    1. INSERM, U790, 39 rue Camille Desmoulins, Villejuif
    2. Institut Gustave Roussy, 39 rue Camille Desmoulins, Villejuif
    3. Université Paris XI, 39 rue Camille Desmoulins, Villejuif, France
    Search for more papers by this author
  • N. DEBILI,

    1. INSERM, U790, 39 rue Camille Desmoulins, Villejuif
    2. Institut Gustave Roussy, 39 rue Camille Desmoulins, Villejuif
    3. Université Paris XI, 39 rue Camille Desmoulins, Villejuif, France
    Search for more papers by this author
  • W. VAINCHENKER

    1. INSERM, U790, 39 rue Camille Desmoulins, Villejuif
    2. Institut Gustave Roussy, 39 rue Camille Desmoulins, Villejuif
    3. Université Paris XI, 39 rue Camille Desmoulins, Villejuif, France
    Search for more papers by this author

William Vainchenker, INSERM, U790, 39 rue Camille Desmoulins, 94805 Villejuif, France.
Tel.: +33 142114233; fax: +33 142115240.
E-mail: verpre@igr.fr

Abstract

Summary.  Each day in every human, approximately 1 × 1011 platelets are produced by the cytoplasmic fragmentation of megakaryocytes (MK), their marrow precursor cells. Platelets are the predominating factor in the process of hemostasis and thrombosis. Recent studies have shown that platelets also play a hitherto unsuspected role in several other processes such as inflammation, innate immunity, neoangiogenesis and tumor metastasis. The late phases of MK differentiation identified by polyploidization, maturation and organized fragmentation of the cytoplasm leading to the release of platelets in the blood stream represent a unique model of differentiation. The molecular and cellular mechanisms regulating platelet biogenesis are better understood and may explain several platelet disorders. This review focuses on MK polyploidization, and platelet formation, and discusses their alteration in some platelet disorders.

Ancillary