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Update of the guidelines for lupus anticoagulant detection

  1. V. PENGO1,
  2. A. TRIPODI2,
  3. G. REBER3,
  4. J. H. RAND4,
  5. T. L. ORTEL5,
  6. M. GALLI6,
  7. P. G. DE GROOT7

Article first published online: 17 JUL 2009

DOI: 10.1111/j.1538-7836.2009.03555.x

Issue

Journal of Thrombosis and Haemostasis

Journal of Thrombosis and Haemostasis

Volume 7, Issue 10, pages 1737–1740, October 2009

Additional Information

How to Cite

PENGO, V., TRIPODI, A., REBER, G., RAND, J. H., ORTEL, T. L., GALLI, M. and DE GROOT, P. G. (2009), Update of the guidelines for lupus anticoagulant detection. Journal of Thrombosis and Haemostasis, 7: 1737–1740. doi: 10.1111/j.1538-7836.2009.03555.x

Author Information

  1. 1

    Clinical Cardiology, Thrombosis Center, University Hospital, Padova

  2. 2

    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy

  3. 3

    Haemostasis Unit, Division of Angiology and Haemostasis, University Hospital, Geneva, Switzerland

  4. 4

    Hematology and Advanced Coagulation Laboratory, Montefiore Medical Center, Bronx, NY

  5. 5

    Division of Hematology, Duke University Medical Center, Durham, NC, USA

  6. 6

    Department of Hematology, Ospedali Riuniti, Bergamo, Italy

  7. 7

    Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, the Netherlands

*Vittorio Pengo, Clinical Cardiology, Department of Cardiac Thoracic and Vascular Sciences, Thrombosis Center, University of Padua, School of Medicine, Via Giustiniani, 2, 35128 Padova, Italy. Tel.: +39 49 821 5658; fax: +39 49 821 5658. E-mail: vittorio.pengo@unipd.it

Publication History

  1. Issue published online: 22 SEP 2009
  2. Article first published online: 17 JUL 2009

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Keywords:

  • anticoagulants;
  • antiphospholipid syndrome;
  • diagnosis;
  • lupus anticoagulant;
  • thrombosis

Summary.  One of the conclusions of the subcommittee meeting on Lupus Anticoagulant/Phospholipid dependent antibodies, held in Geneva on 2007, was the need to update the guidelines on Lupus Anticoagulant (LA) detection. Particular emphasis was given to several aspects discussed in this official communication. A new paragraph is dedicated to the patient selection, and aims to minimize inappropriate requests for LA testing. Modalities for blood collection and processing are fully delineated and the choice of tests is limited to dRVVT and a sensitive aPTT. Calculation of cut-off values for each diagnostic step are clearly stated. A final paragraph reports the interpretation of the results in general and in particular situations.

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