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Data S1. Additional details about Methods, Included studies Chracteristics and Analysis Results.

Table S1. Characteristics of included studies.

Table S2. List of topics included in the extraction sheet.

Fig. S1. Meta-analysis of single arm studies (pooled incidence rates).

Fig. S2. Meta-analysis of double arm studies (pooled rate ratio): HR inhibitors.

Fig. S3. L’Abbe plot.

Fig. S4. Meta-analysis of double arm studies (pooled rate ratio): low responder inhibitors.

Fig. S5. L’Abbe plot.

Fig. S6. Meta-analysis of double arm studies (pooled rate ratio): all inhibitors.

Fig. S7. L’Abbe plot.

Appendix S1. Details about unpublished studies included in the analysis.

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Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.