Incidence and cumulative recurrence rates of venous thromboembolism in the Taiwanese population

Authors

  • C.-H. LEE,

    1. Department of Internal Medicine, National Cheng Kung University Hospital
    2. Institute of Biopharmaceutical Science, College of Medicine, National Cheng Kung University
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    • 1

      These authors contributed equally.

  • L.-J. LIN,

    1. Department of Internal Medicine, National Cheng Kung University Hospital
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    • 1

      These authors contributed equally.

  • C.-L. CHENG,

    1. Institute of Biopharmaceutical Science, College of Medicine, National Cheng Kung University
    2. Institute of Clinical Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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  • Y.-H. KAO YANG,

    1. Institute of Biopharmaceutical Science, College of Medicine, National Cheng Kung University
    2. Institute of Clinical Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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  • J.-Y. CHEN,

    1. Department of Internal Medicine, National Cheng Kung University Hospital
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  • L.-M. TSAI

    1. Department of Internal Medicine, National Cheng Kung University Hospital
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Yea-Huei Kao Yang, Institute of Clinical Pharmacy and Institute of Biopharmaceutical Science, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan.
Tel.: +886 6 2353535 ext. 5688; fax: +886 6 2373149.
E-mail: yhkao@mail.ncku.edu.tw

Abstract

Summary. Background: Little information is available on the epidemiology of venous thromboembolism (VTE) in Asian populations. Objectives: To investigate VTE incidence, VTE cumulative recurrence rates and risk factors for VTE recurrence among the adult Taiwanese population. Methods: This population-based cohort study used the Taiwanese National Health Insurance claims databases to identify 5347 adult patients (2463 men, 46.1%) with VTE diagnosed in 2001 and 2002. We calculated the crude incidence of VTE and its recurrence. We also conducted a nested case–control study (n = 3576) among this population to estimate the association between VTE recurrence and exposure to potential VTE risk factors by conditional logistic regression. Results: The crude incidence of VTE was 15.9 per 100 000 person-years, and its recurrence rate was 5.1% per person-year. During 11 566 person-years of follow-up, the cumulative rates of VTE recurrence at 6, 12, 24, 36 and 47 months were 6.7%, 9.4%, 12.4%, 13.9%, and 14.4%, respectively. By conditional logistic regression, histories of VTE [adjusted odds ratio (OR) 1.71, 95% confidence interval (CI) 1.32–2.16] or malignant neoplasm (adjusted OR 1.64, 95% CI 1.26–1.99), major extremity trauma (adjusted OR 2.76, 95% CI 1.82–4.52), serious neurologic diseases (adjusted OR 1.43, 95% CI 1.12–1.84) or undergoing major surgery (adjusted OR 4.57, 95% CI 1.72–12.50) were associated with higher risks of VTE recurrence. Conclusions: The incidence of VTE is lower in the Taiwanese population than in Caucasians. Most VTE recurrences occur within 12 months, but they continue to occur beyond 1 year. The VTE recurrences are associated with malignancy, history of VTE, and major surgery after a previous VTE.

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