COX-1+/−COX-2−/− genotype in mice is associated with shortened time to carotid artery occlusion through increased PAI-1
Article first published online: 27 JAN 2011
© 2011 International Society on Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis
Volume 9, Issue 2, pages 350–360, February 2011
How to Cite
RIEHL, T. E., HE, L., ZHENG, L., GRECO, S., TOLLEFSEN, D. M. and STENSON, W. F. (2011), COX-1+/−COX-2−/− genotype in mice is associated with shortened time to carotid artery occlusion through increased PAI-1. Journal of Thrombosis and Haemostasis, 9: 350–360. doi: 10.1111/j.1538-7836.2010.04156.x
- Issue published online: 27 JAN 2011
- Article first published online: 27 JAN 2011
- Accepted manuscript online: 7 DEC 2010 10:48AM EST
- Received 29 April 2010, accepted 19 November 2010
Data S1. Clot lysis assay.
Table S1. (A) The percent occurrence of genotypes in progeny of all combinations of COX-1 and COX-2 breeders on the C57BL/6J genetic background shows that progeny genotypes approximate Mendelian expectations for the COX-1−/− genotype, but are less than Mendelian expectations for the COX-2−/− genotype. Data show percent occurrence of genotypes, with Mendelian expectations in parentheses. (B) Extent of breeding program for COX-1 and COX-2 mice over a 3 year period.
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