Nanoscale studies of protein-membrane interactions in blood clotting


James H. Morrissey, Biochemistry Department, University of Illinois College of Medicine, 417 Med. Sci. Bldg. MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
Tel.: +1 217 265-4036; fax: +1 217 265-5290.


Summary.  Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.