Nanoscale studies of protein-membrane interactions in blood clotting

Authors


James H. Morrissey, Biochemistry Department, University of Illinois College of Medicine, 417 Med. Sci. Bldg. MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.
Tel.: +1 217 265-4036; fax: +1 217 265-5290.
E-mail: jhmorris@illinois.edu

Abstract

Summary.  Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.

Ancillary