Protein kinase C alpha and beta are positive regulators of thrombus formation in vivo in a zebrafish (Danio rerio) model of thrombosis
Article first published online: 1 DEC 2011
© 2011 International Society on Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis
Volume 9, Issue 12, pages 2457–2465, December 2011
How to Cite
WILLIAMS, C. M., FENG, Y., MARTIN, P. and POOLE, A. W. (2011), Protein kinase C alpha and beta are positive regulators of thrombus formation in vivo in a zebrafish (Danio rerio) model of thrombosis. Journal of Thrombosis and Haemostasis, 9: 2457–2465. doi: 10.1111/j.1538-7836.2011.04520.x
- Issue published online: 1 DEC 2011
- Article first published online: 1 DEC 2011
- Accepted manuscript online: 27 SEP 2011 11:30AM EST
- Received 15 March 2011, accepted 1 September 2011
Figure S1. Expected truncation of PKCα and PKCβ protein sequences after the action of the relevant splice-blocking morpholinos.
Figure S2. Conserved synteny between human and zebrafish PKCa and PKCb. The syntenic analysis was performed on the human and zebrafish chromosomes containing PKCa (PRKCA) and PKCb (PRKCB) using SyMAP v3.4 (Soderlund et al., Nucleic Acids Res, 2011; 39: e68) with syntenic hits between chromosomes represented by intersecting lines. The Ensembl zebrafish and human genome databases were manually queried to determine the local genomic neighbours (genes within 2 MB) that are conserved between human and zebrafish PRKCA and PRKCB, with the conserved genes displayed.
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