• 1
    Mannucci PM, Tuddenham EG. The hemophiliac – from royal genes to gene therapy. N Engl J Med 2001; 344: 17739.
  • 2
    Tagliaferri A, Rivolta GF, Iorio A, Oliovecchio E, Mancuso ME, Morfini M, Rocino A, Mazzucconi MG, Franchini M; Italian Association of Hemophilia Centers. Mortality and causes of death in Italian persons with haemophilia, 1990–2007. Haemophilia 2010; 16: 43746.
  • 3
    Franchini M, Mannucci PM. Co-morbidities and quality of life in elderly persons with haemophilia. Br J Haematol 2010; 148: 52233.
  • 4
    Franchini M, Tagliaferri A, Mannucci PM. The management of hemophilia in elderly patients. Clin Interv Aging 2007; 2: 3618.
  • 5
    Franchini M, Lippi G, Montagnana M, Targher G, Zaffanello M, Salvagno GL, Rivolta GF, Perna CD, Tagliaferri A. Hemophilia and cancer: a new challenge for hemophilia centers. Cancer Treat Rev 2009; 35: 3747.
  • 6
    Miesbach W, Seifried E. Does hemophilia influence cancer-related mortality in HIV-negative patients? Haemophilia 2011; 17: 5560.
  • 7
    Mauser-Bunschoten EP, Fransen van de Putte DE, Schutgens REG. Co-morbidity in the ageing haemophilia patient: the down side of increased life expectancy. Haemophilia 2009; 15: 85363.
  • 8
    Dolan G. The challenge of an ageing haemophilic population. Haemophilia 2010; 16(Suppl. 5): 116.
  • 9
    Dunn AL. Malignancy in patients with haemophilia: a review of the literature. Haemophilia 2010; 16: 42736.
  • 10
    Cáceres W, Cruz-Amy M, Díaz-Meléndez V. AIDS-related malignancies: revisited. P R Health Sci J 2010; 29: 705.
  • 11
    Marcucci F, Mele A. Hepatitis viruses and non-Hodgkin lymphoma: epidemiology, mechanisms of tumorigenesis, and therapeutic opportunities. Blood 2011; 117: 17928.
  • 12
    Konkle BA, Kessler C, Aledort L, Andersen J, Fogarty P, Kouides P, Quon D, Ragni M, Zakarija A, Ewenstein B. Emerging clinical concerns in the ageing haemophilia patient. Haemophilia 2009; 15: 1197209.
  • 13
    Langer F, Amirkhosravi A, Ingersoll SB, Walker JM, Spath B, Eifrig B, Bokemeyer C, Francis JL. Experimental metastasis and primary tumor growth in mice with hemophilia A. J Thromb Haemost 2006; 4: 105662.
  • 14
    Bruggemann LW, Versteeg HH, Niers TM, Reitsma PH, Spek CA. Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders. J Cell Biol Med 2008; 12: 26227.
  • 15
    Mannucci PM, Schutgens REG, Santagostino E, Mauser-Bunschoten EPM. How I treat age-related morbidities in elderly persons with hemophilia. Blood 2009; 114: 525663.
  • 16
    Walker IR, Julian JA. Association of Hemophilia Clinic Directors of Canada. Causes of death in Canadians with haemophilia 1980–1995. Haemophilia 1998; 4: 71420.
  • 17
    Darby SC, Kan SW, Spooner RJ, Giangrande PL, Hill FG, Hay CR, Lee CA, Ludlam CA, Williams M. Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV. Blood 2007; 110: 81525.
  • 18
    Plug I, van der Bom JG, Peters M, De Goede-Bolder A, Heijnen L, Smit C, Willemse J, Rosendaal FR. Mortality and causes of death in patients with hemophilia, 1992–2001: a prospective cohort study. J Thromb Haemost 2006; 4: 5106.
  • 19
    Miesbach W, Alesci S, Krekeler S, Seifried E. Comorbidities and bleeding pattern in elderly haemophilia A patients. Haemophilia 2009; 15: 8949.
  • 20
    Miesbach W. Multicentric study about the incidence of cancer in patients with haemophilia and registry of patients with haemophilia and cancer. Haemophilia 2011; 17: 46 (abstract).
  • 21
    Franchini M, Rossetti G, Tagliaferri A, Capra F, de Maria E, Pattacini C, Lippi G, Lo Cascio G, de Gironcoli M, Gandini G. The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders. Blood 2001; 98: 183641.
  • 22
    Soucie JM, Nuss R, Evatt B, Abdelhak A, Cowan L, Hill H, Kolakoski M, Wilber N. Mortality among males with hemophilia: relations with source of medical care. The Hemophilia Surveillance System Project Investigators. Blood 2000; 96: 43742.