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Figure S1. Scatter plots of the coagulation tests in 310 patients.

Figure S2. Linkage analysis in an pedigree with the PROC c.574_576del variant.

Figure S3. Multiple sequence alignment of Protein C among different species.

Table S1. Primers and annealing temperatures for amplification.

Table S2. Mutations and clinical data for patients with low PC or PS activity.

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