Fig. S1. Scheme of blood withdrawal from rabbits; preparations of PRP, PPP, and washed RBC, and transfusion of washed RBC into rabbits.

Fig. S2. Non-compressible liver hemorrhage in thrombocytopenic rabbits.

Fig. S3. Changes in hematological parameters by blood exchange.

Fig. S4. Histological findings of the lung, liver, kidney and spleen 2 weeks after administration of H12-(ADP)-liposomes and liver hemorrhage in the thrombocytopenic rabbits.

Table S1. Changes in coagulation factors in rabbits after blood exchange.

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