Formation of platelet-binding von Willebrand factor strings on non-endothelial cells
Article first published online: 1 OCT 2012
© 2012 International Society on Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis
Volume 10, Issue 10, pages 2168–2178, October 2012
How to Cite
WANG, J. W., VALENTIJN, J. A., VALENTIJN, K. M., DRAGT, B. S., VOORBERG, J., REITSMA, P. H. and EIKENBOOM, J. (2012), Formation of platelet-binding von Willebrand factor strings on non-endothelial cells. Journal of Thrombosis and Haemostasis, 10: 2168–2178. doi: 10.1111/j.1538-7836.2012.04891.x
- Issue published online: 1 OCT 2012
- Article first published online: 1 OCT 2012
- Accepted manuscript online: 20 AUG 2012 10:21AM EST
- Received 23 May 2012, accepted 10 August 2012
Figure S1. VWF string formation is independent of signaling pathways inducing pseudo-WPB exocytosis.
Figure S2. P-selectin is not required for VWF string formation.
Figure S3. Measurement of the exocytosis of pseudo-WPB.
Figure S4. Additional examples of platelet-decorated VWF strings anchored on the cell surface of HEK293 cells.
Video Clip S1. A platelet-decorated VWF string (bundle) remained on the cells surface more than 15 minutes under fluid flow.
Video Clip S2. Dynamics of VWF strings under flow.
Video Clip S3. Growth of VWF strings under flow.
Video Clip S4. VWF-GFP unfurled into strings and bound platelets at higher shear stress.
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