• 1
    Narayanan S, Hamasaki N. Current concepts of coagulation and fibrinolysis. Adv Clin Chem 1999; 33: 13368.
  • 2
    Aiach M, Borgel D, Gaussem P, Emmerich J, Alhenc-Gelas M, Gandrille S. Protein C and protein S deficiencies. Semin Hematol 1997; 34: 20516.
  • 3
    Castoldi E, Rosing J. APC resistance: biological basis and acquired influences. J Thromb Haemost 2010; 8: 44553.
  • 4
    Dahlback B. Resistance to activated protein C as risk factor for thrombosis: molecular mechanisms, laboratory investigation, and clinical management. Semin Hematol 1997; 34: 21734.
  • 5
    Roberts LN, Patel K, Arya R. Venous thromboembolism and ethnicity. Br J Haematol 2009; 46: 36983.
  • 6
    Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 10048.
  • 7
    Koster T, Rosendaal FR, de Ronde H, Briët E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993; 342: 15036.
  • 8
    Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 646.
  • 9
    Rosendaal FR. Risk factors for venous thrombosis: prevalence, risk, and interaction. Semin Hematol 1997; 34: 17187.
  • 10
    Shen MC, Lin JS, Tsay W. High prevalence of antithrombin III, protein C and protein S deficiency, but no factor V Leiden mutation in venous thrombophilic Chinese patients in Taiwan. Thromb Res 1997; 87: 37785.
  • 11
    Liu HW, Kwong YL, Bourke C, Lam CK, Lie AK, Wei D, Chan LC. High incidence of thrombophilia detected in Chinese patients with venous thrombosis. Thromb Haemost 1994; 71: 41619.
  • 12
    Tang L, Lu X, Yu JM, Wang QY, Yang R, Guo T, Mei H, Hu Y. PROC c.574_576del polymorphism: a common genetic risk factor for venous thrombosis in Chinese population. J Thromb Haemost 2012; 10: 201926.
  • 13
    Tang L, Guo T, Yang R, Mei H, Wang H, Lu X, Yu J, Wang Q, Hu Y. Genetic background analysis of protein C deficiency demonstrates a recurrent mutation associated with venous thrombosis in Chinese population. PLoS ONE 2012; 7: e35773.
  • 14
    Kinoshita S, Iida H, Inoue S, Watanabe K, Kurihara M, Wada Y, Tsuda H, Kang D, Hamasaki N. Protein S and protein C gene mutations in Japanese deep vein thrombosis patients. Clin Biochem 2005; 38: 90815.
  • 15
    Hamasaki N. Japanese thrombophilia: protein S/protein C anomaly as the major risk factor for Japanese thrombophilia. Jpn J Thromb Haemost 2006; 17: 13643 (in Japanese).
  • 16
    Shigekiyo T, Uno Y, Kawauchi S, Saito S, Hondo H, Nishioka J, Hayashi T, Suzuki K. Protein S Tokushima: an abnormal protein S found in a Japanese family with thrombosis. Thromb Haemost 1993; 70: 2446.
  • 17
    Yamazaki Y, Sugiura I, Matsushita T, Kojima T, Kagami K, Takamatsu J, Saito H. A phenotypically neutral dimorphism of protein S: the substitution of Lys155 by Glu in the second EGF domain predicted by an A to G base exchange in the gene. Thromb Res 1993; 70: 395403.
  • 18
    Tsuda H, Urata M, Tsuda T, Wakiyama M, Iida H, Nakahara M, Kinoshita S, Hamasaki N. Four missense mutations identified in the protein S gene of thrombosis patients with protein S deficiency: effects on secretion and anticoagulant activity of protein S. Thromb Res 2002; 105: 2339.
  • 19
    Kimura R, Honda S, Kawasaki T, Tsuji H, Madoiwa S, Sakata Y, Kojima T, Murata M, Nishigami K, Chiku M, Hayashi T, Kokubo Y, Okayama A, Tomoike H, Ikeda Y, Miyata T. Protein S-K196E mutation as a genetic risk factor for deep vein thrombosis in Japanese patients. Blood 2006; 107: 17378.
  • 20
    Ikejiri M, Wada H, Sakamoto Y, Ito N, Nishioka J, Nakatani K, Tsuji A, Yamada N, Nakamura M, Ito M, Nobori T. The association of protein S Tokushima-K196E with a risk of deep vein thrombosis. Int J Hematol 2010; 92: 3025.
  • 21
    Hamasaki N, Kanaji T. Clinical role of protein S deficiency in Asian population. In: Tanaka K, Davie EW, eds. Recent Advances in Thrombosis and Hemostasis. Springer, 2008: 597613.
  • 22
    Heit J, Beckman MG, Bockenstedt PL, Grant AM, Key NS, Kulkarni R, Manco-Johnson MJ, Moll S, Ortel TL, Philipp CS. Comparison of characteristics from White- and Black-Americans with venous thromboemoblism: a cross-sectional study. Am J Hematol 2010; 85: 46771.