These authors contributed equally to this work.
Increased platelet activation and thrombosis in transgenic mice expressing constitutively active P2Y12
Article first published online: 1 OCT 2012
© 2012 International Society on Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis
Volume 10, Issue 10, pages 2149–2157, October 2012
How to Cite
ZHANG, Y., YE, J., HU, L., ZHANG, S., ZHANG, S. H., LI, Y., KUNAPULI, S. P. and DING, Z. (2012), Increased platelet activation and thrombosis in transgenic mice expressing constitutively active P2Y12. Journal of Thrombosis and Haemostasis, 10: 2149–2157. doi: 10.1111/j.1538-7836.2012.04894.x
- Issue published online: 1 OCT 2012
- Article first published online: 1 OCT 2012
- Accepted manuscript online: 20 AUG 2012 10:25AM EST
- Received 13 April 2012, accepted 3 August 2012
Fig. S1. Transgene expression is doxycycline-inducible and platelet-specific.
Fig. S2. The P-selective expression and αIIbβ3 activation is similar under basal conditions on platelets from wild-type and transgenic mice.
Fig. S3. AR-C69931MX slightly inhibits platelet aggregation induced by serotonin in doxycycline treated transgenic mice.
Fig. S4. Real-time PCR detection of the expression of endogenous P2Y12 and cP2Y12 transgene in platelets of transgenic mice treated with doxycycline.
Video Clip S1. Thrombus formation in wild type mice.
Video Clip S2. Increased thrombus formation in doxycycline-treated cP2Y12 transgenic mice.
Data S1. Expanded materials and methods.
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