Fig. S1. Transgene expression is doxycycline-inducible and platelet-specific.

Fig. S2. The P-selective expression and αIIbβ3 activation is similar under basal conditions on platelets from wild-type and transgenic mice.

Fig. S3. AR-C69931MX slightly inhibits platelet aggregation induced by serotonin in doxycycline treated transgenic mice.

Fig. S4. Real-time PCR detection of the expression of endogenous P2Y12 and cP2Y12 transgene in platelets of transgenic mice treated with doxycycline.

Video Clip S1. Thrombus formation in wild type mice.

Video Clip S2. Increased thrombus formation in doxycycline-treated cP2Y12 transgenic mice.

Data S1. Expanded materials and methods.

JTH_4894_sm_Doc-S1.doc46KSupporting info item
JTH_4894_sm_FigS1.tif1026KSupporting info item
JTH_4894_sm_FigS2.tif480KSupporting info item
JTH_4894_sm_FigS3.tif200KSupporting info item
JTH_4894_sm_FigS4.tif327KSupporting info item
JTH_4894_sm_videoS1.wmv23366KSupporting info item
JTH_4894_sm_videoS2.wmv22432KSupporting info item

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.