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Figure S1. Backbone RMSD (Root Mean Square Deviations) profiles of MD simulations for TF1-242/fVIIa on a 4:1 POPC/POPS bilayer model: (a) RMSD profile of TF1-242/fVIIa for the Amber simulation (b) RMSD profiles of specific fragments of TF1-242 for the Amber simulation (c) RMSD profile of TF1-242/fVIIa for the NAMD simulation.

Figure S2. Time profiles of active site height from phospholipid bilayer surface over the last 10 ns period for the Amber and NAMD simulations.

Figure S3. Estimates for ternary complexes of TF1-242/fVIIa/fXa from the final snapshots of Amber and NAMD simulations: (a) Amber ternary model (b) NAMD ternary model

Table S1. Summary of the systems and MD simulations for TF1-242/fVIIa on a 4:1 POPC/POPS bilayer model.

Table S2. Interaction patterns between protein and lipid: (a) TF (b) GLA domain.

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