Division of Cancer Prevention and Control Research, UCLA, Los Angeles, CA, USA.
Section I: Model Inputs
Chapter 6: Lung Cancer in Never Smokers: Epidemiology and Risk Prediction Models
Article first published online: 7 AUG 2012
© 2012 Society for Risk Analysis
Special Issue: The Impact of the Reduction in Tobacco Smoking on U.S. Lung Cancer Mortality (1975-2000): Collective Results from the Cancer Intervention and Surveillance Modeling Network (CISNET)
Volume 32, Issue Supplement s1, pages S69–S84, August 2012
How to Cite
McCarthy, W. J., Meza, R., Jeon, J. and Moolgavkar, S. H. (2012), Chapter 6: Lung Cancer in Never Smokers: Epidemiology and Risk Prediction Models. Risk Analysis, 32: S69–S84. doi: 10.1111/j.1539-6924.2012.01768.x
- Issue published online: 7 AUG 2012
- Article first published online: 7 AUG 2012
- Lung cancer;
- never smokers;
- risk prediction models
In this chapter we review the epidemiology of lung cancer incidence and mortality among never smokers/nonsmokers and describe the never smoker lung cancer risk models used by the Cancer Intervention and Surveillance Network (CISNET) modelers. Our review focuses on those influences likely to have measurable population impact on never smoker risk, such as secondhand smoke, even though the individual-level impact may be small. Occupational exposures may also contribute importantly to the population attributable risk of lung cancer. We examine the following risk factors in this chapter: age, environmental tobacco smoke, cooking fumes, ionizing radiation including radon gas, inherited genetic susceptibility, selected occupational exposures, preexisting lung disease, and oncogenic viruses. We also compare the prevalence of never smokers between the three CISNET smoking scenarios and present the corresponding lung cancer mortality estimates among never smokers as predicted by a typical CISNET model.