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Chapter 6: Lung Cancer in Never Smokers: Epidemiology and Risk Prediction Models

Authors

  • William J. McCarthy,

    Corresponding author
      William J. McCarthy, Ph.D., UCLA Division of Cancer Prevention & Control Research, A2-125 CHS, Box 690015, 650 Charles Young Drive, Los Angeles, CA 90095-6900, USA; wmccarth@ucla.edu.
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    • Division of Cancer Prevention and Control Research, UCLA, Los Angeles, CA, USA.

    • Department of Psychology, UCLA, Los Angeles, CA, USA.

    • Erasmus University, Rotterdam, The Netherlands.

  • Rafael Meza,

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    • Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.

  • Jihyoun Jeon,

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    • Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

  • Suresh H. Moolgavkar

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    • Fred Hutchinson Cancer Research Center, Seattle, WA, USA.


William J. McCarthy, Ph.D., UCLA Division of Cancer Prevention & Control Research, A2-125 CHS, Box 690015, 650 Charles Young Drive, Los Angeles, CA 90095-6900, USA; wmccarth@ucla.edu.

Abstract

In this chapter we review the epidemiology of lung cancer incidence and mortality among never smokers/nonsmokers and describe the never smoker lung cancer risk models used by the Cancer Intervention and Surveillance Network (CISNET) modelers. Our review focuses on those influences likely to have measurable population impact on never smoker risk, such as secondhand smoke, even though the individual-level impact may be small. Occupational exposures may also contribute importantly to the population attributable risk of lung cancer. We examine the following risk factors in this chapter: age, environmental tobacco smoke, cooking fumes, ionizing radiation including radon gas, inherited genetic susceptibility, selected occupational exposures, preexisting lung disease, and oncogenic viruses. We also compare the prevalence of never smokers between the three CISNET smoking scenarios and present the corresponding lung cancer mortality estimates among never smokers as predicted by a typical CISNET model.

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