Original Research Article
A Calibrated Human PBPK Model for Benzene Inhalation with Urinary Bladder and Bone Marrow Compartments
Article first published online: 24 DEC 2012
© 2012 Society for Risk Analysis
Volume 33, Issue 7, pages 1237–1251, July 2013
How to Cite
Knutsen, J. S., Kerger, B. D., Finley, B. and Paustenbach, D. J. (2013), A Calibrated Human PBPK Model for Benzene Inhalation with Urinary Bladder and Bone Marrow Compartments. Risk Analysis, 33: 1237–1251. doi: 10.1111/j.1539-6924.2012.01927.x
- Issue published online: 8 JUL 2013
- Article first published online: 24 DEC 2012
Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.
Appendix A: Parameter Values
Table A1: List of symbols
Table A2: Physiologic parameters used in the model
Table A3: Metabolic kinetic parameters used in the model
Table A4: Partition coefficients used in the model
Table A5: Background metabolite parameters used in the model
Appendix B: Mathematical Model
Appendix C: Additional Validation Studies
Figure C1: Breath measurements following cessation of occupational exposure, as reported by Berlin et al.(36) Model results are for 8 hours of exposure to 0.5 ppm benzene, followed by a background exposure of 0.005 ppm.
Figure C2: Breath concentrations measured by Nomiyama and Nomiyama during 4 hours of exposure to 57 ppm benzene.(37,38)
Figure C3: Results of Sherwood(40) and model predictions for four exposure scenarios.
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