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The theory of aligned ambition posits that adolescents’ career aspirations are shaped by both contextual and attitudinal factors. Minority students are less likely to exhibit career-specific knowledge, realistic attitudes, and successful behaviors, which could exacerbate racial disparities in the health care workforce. This article describes the theoretical grounding and preliminary implementation of an intervention designed to promote aligned ambition from an early stage of career development. The Training Early Achievers for Careers in Health Research Program provides exposure to realistic career experiences and multitiered mentorship, with the goal of cultivating aligned ambition toward clinical research careers among minority high school students. We discuss program operations in detail and consider whether this method can be used nationally to promote entry of minority youth into clinical research careers.