Disclosure: This work was supported by a grant from the Korea Health 21 R&D Project (A085136), Ministry of Health and Welfare, Republic of Korea.
Flecainide-Associated Bradycardia-Dependent Torsade de Pointes: Another Potential Mechanism of Proarrhythmia
Article first published online: 28 OCT 2010
©2010, The Authors. Journal compilation ©2010 Wiley Periodicals, Inc.
Pacing and Clinical Electrophysiology
Volume 36, Issue 3, pages e84–e86, March 2013
How to Cite
KIM, H. S., PAK, H.-N., PARK, J. S. and KIM, S. S. (2013), Flecainide-Associated Bradycardia-Dependent Torsade de Pointes: Another Potential Mechanism of Proarrhythmia. Pacing and Clinical Electrophysiology, 36: e84–e86. doi: 10.1111/j.1540-8159.2010.02935.x
- Issue published online: 5 MAR 2013
- Article first published online: 28 OCT 2010
- Manuscript Accepted: 5 AUG 2010
- Manuscript Revised: 17 JUL 2010
- Manuscript Received: 10 JUN 2010
- Korea Health 21 R&D. Grant Number: A085136
- Ministry of Health and Welfare
- torsade de pointes
Although flecainide has a risk of proarrhythmia in patients with structural heart disease, its mechanism has been mainly ascribed to use-dependency and a rapid ventricular response to organized atrial tachyarrhythmias or to ventricular tachycardia. We present a patient who experienced recurrent syncope due to bradycardia-dependent torsade de pointes (TdP) associated with flecainide-related bradycardia and QT prolongation. Bradycardia-dependent TdP with QT prolongation can be considered as one of mechanisms of flecainide-induced proarrhythmia.