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Initial Single-Center Experience of a Quadripolar Pacing Lead for Cardiac Resynchronization Therapy


  • Conflicts of interest: AK Shetty is supported by an Educational grant from St. Jude Medical. CA Rinaldi has received research funding from St. Jude Medical and has consultancy agreements with St. Jude Medical, Medtronic, and Boston Scientific.

Address for reprints: Anoop Shetty, M.D., St. Thomas’ Hospital, Westminster Bridge Road, London SE1 7EH, United Kingdom. Fax: 442071885442; e-mail:


Background: The Quartet model 1458Q (St. Jude Medical, Sylmar, CA, USA) lead is a quadripolar left ventricular (LV) lead with pace/sense capability from four electrodes (tip and three rings). The lead is capable of pacing in 10 different configurations rather than the three that are available in conventional bipolar pacing leads. We describe a single-center initial experience of the use of this lead in patients undergoing cardiac resynchronization therapy (CRT).

Methods: Twenty-eight patients for a CRT with cardiac defibrillator were implanted between October 2009 and May 2010 with a Quartet lead. Lead position, pacing parameters, stability, complications, and presence of phrenic nerve stimulation (PNS) data were collected at implant and predischarge. Follow-up data were collected at 15 ± 8 weeks for all patients.

Results: A Quartet lead was successfully implanted in 96% (27/28) of patients (age 61 ± 15 years; 82% male; ischemic etiology 50%; mean left ventricular [LV] ejection fraction 25 ± 7%; left bundle branch block 68%). PNS was seen at implant in 11 patients (41%) with at least one vector. In eight of these cases (72%), the need for lead repositioning was averted by programming LV pacing utilizing the additional vectors available with the Quartet lead.

Conclusion: These initial data suggest that pacing with the Quartet lead is associated with a high implant success rate and stable pacing parameters acutely and at short-term follow-up. The 10 LV pacing vectors available with this lead may allow PNS and capture threshold problems to be easily overcome. (PACE 2011; 34:484–489)