Regional Ganglionated Plexus Ablation Eliminated Rapid Firing in an Electrically Isolated Pulmonary Vein


  • Financial Support: Chenyang Jiang is supported by Science and Technology Key Project of Zhejiang Province, China (2009C33124).

Address for correspondence: Chen-yang Jiang, M.D., Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, Zhejiang, 310016, P.R.China. Fax: 0086-0571-86945874; e-mail:


Atrial fibrillation (AF) was initiated by rapid firing from left superior pulmonary vein (PV) by administration of isoproterenol (ISP) and adenosine triphosphate (ATP) before ablation. After successful isolation of all PVs, ISP and ATP were administered again. PVs were still isolated but an episode of rapid firing was observed inside the left PV isolation line during sinus rhythm. Radiofrequency energy was then delivered to the areas of superior left ganglionated plexus (GP) and inferior left GP. Then, PV firing could no longer be initiated. It suggests additional GP ablation may have additional benefit to circumferential PV isolation, to reduce the incidence of AF recurrence. (PACE 2012; 35:e316–e319)