Profound Sinus Node Dysfunction in Anti-N-Methyl-D-Aspartate Receptor Limbic Encephalitis


  • Conflict of interest/Financial Disclosure: Nil

Address for reprints: Pow-Li Chia, M.B.B.S., Tan Tock Seng Hospital, Department of Cardiology, 11 Jalan Tan Tock Seng, Singapore 308433. Fax: +65 63526682; e-mail:


A form of limbic encephalitis associated with antibodies against the N-methyl-D-aspartate receptor (NMDAR) was discovered in 2007. It is often a multistage illness that progresses from psychosis, memory deficits, seizures into a state of unresponsiveness with catatonic features, abnormal movements, autonomic, and respiratory instability. We present two cases of anti-NMDAR encephalitis to highlight the cardiac complications and their management.