Antibodies to Beta-Adrenergic Receptors Disclosing Agonist-Like Properties in Idiopathic Dilated Cardiomyopathy and Chagas’ Heart Disease

Authors

  • MAURICIO B. ROSENBAUM M.D.,

    Corresponding author
    1. Service of Cardiology, Ramos Mejia Hospital, and the Institute de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI), Buenos Aires, Argentina
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  • PABLO A. CHIALE M.D.,

    1. Service of Cardiology, Ramos Mejia Hospital, and the Institute de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI), Buenos Aires, Argentina
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  • DALIA SCHEJTMAN M.D.,

    1. Service of Cardiology, Ramos Mejia Hospital, and the Institute de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI), Buenos Aires, Argentina
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  • MARIANO LEVIN ph. d.,

    1. Service of Cardiology, Ramos Mejia Hospital, and the Institute de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI), Buenos Aires, Argentina
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  • MARCELO V. ELIZARI M.D.

    1. Service of Cardiology, Ramos Mejia Hospital, and the Institute de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI), Buenos Aires, Argentina
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  • This work was supported in part by the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (Grant 900253) and the Fundacion de Investigaciones Cardiologicas Einthoven.

Mauricio B. Rosenbaum, M.D., Service of Cardiology, Ramos Mejia Hospital, Urquiza 609, First Floor, 1221 Buenos Aires, Argentina. Fax: 54-1-326-0752.

Abstract

Antibodies to Beta-Adrenergic Receptors. Recent studies confirm the existence of antibodies (Abs) to β adrenoceptors in patients with idiopathic dilated cardiomyopathy and Chagas’ heart disease. These Abs can be shown to exert both stimulatory and inhibitory effects, which may play a role in the development of the cardiac abnormalities known to occur in these diseases, including advanced heart failure. The hypothesis is advanced that Chagas’ heart disease and some forms of idiopathic dilated cardiomyopathy may represent, at least partially, a form of “adrenergic cardiomyopathy.”

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