Marl Watanabe M.D., is a Howard Hughes Medical Institute Predoctoral Fellow.
Impulse Formation and Conduction of Excitation in the Atrioventricular Node
Article first published online: 29 APR 2007
Journal of Cardiovascular Electrophysiology
Volume 5, Issue 6, pages 517–531, June 1994
How to Cite
WATANABE, Y. and WATANABE, M. (1994), Impulse Formation and Conduction of Excitation in the Atrioventricular Node. Journal of Cardiovascular Electrophysiology, 5: 517–531. doi: 10.1111/j.1540-8167.1994.tb01292.x
- Issue published online: 29 APR 2007
- Article first published online: 29 APR 2007
- Manuscript received 29 September 1992; Accepted for publication 24 March 1994
- atrioventricular nodal conduction;
- conduction hypothesis
AV Nodal Conduction. Meijler et al. have recently challenged the classical concept of AV nodal conduction (the conduction hypothesis) and suggest that the AV node might he controlling ventricular rhythmicity through its automaticity electrotonically modulated In atrial excitation (the modulated pacemaker hypothesis). This article critically evaluates the three major arguments of Meijler: (1) the absence of convincing evidence for conduction of excitation in the AV node; (2) the prevalence of disproportionately short AV intervals in larger animals; and (3) elimination of KR intervals shorter than the cycle length of ventricular pacing during atrial fibrillation, to judge which of these two hypotheses would more satisfactorily explain various experimental and clinical findings accumulated in the past. Previous observations including microelectrode mapping of the rabbit AV junction during regular sinus rhythm as well as second–degree AV block, clinical and experimental studies on concealed conduction, and studies on the ventricular response to atrial fibrillation appear to he compatible with the conduction hypothesis, whereas clearcut evidence for automatic impulse formation in the AV node has not been presented, except in a small number of hearts showing spontaneous AV junctional rhythms. In view of these observations and theoretical considerations based on comparative anatomy of the AV node–His–Purkinje system and on the latest experimental study on the equine AV node, the authors conclude that the conduction hypothesis appears to better explain all the available data, except perhaps in a few cases with second–degree intra–AV nodal block.