Editor: Silvia G. Priori, M.D., Ph.D.
Is Wolff-Parkinson-White Syndrome a Genetic Disease?
Article first published online: 14 JUL 2005
Journal of Cardiovascular Electrophysiology
Volume 16, Issue 11, pages 1258–1262, November 2005
How to Cite
EHTISHAM, J. and WATKINS, H. (2005), Is Wolff-Parkinson-White Syndrome a Genetic Disease?. Journal of Cardiovascular Electrophysiology, 16: 1258–1262. doi: 10.1111/j.1540-8167.2005.50139.x
- Issue published online: 14 SEP 2005
- Article first published online: 14 JUL 2005
Family studies, and more recent molecular genetic investigations, indicate that the Wolff-Parkinson-White (WPW) syndrome and associated preexcitation disorders can have a substantial genetic component. Because preexcitation disorders are sometimes inherited as single gene disorders, key mechanistic insights can be gained that are expected to be relevant also to the more common multifactorial forms of these traits. Potentially, such insights will inform the future management of these conditions. Where WPW is inherited as a familial trait, with or without associated cardiac defects or a systemic syndrome, there are clinical genetic ramifications that are already of practical importance.