Manuscript received 24 November 2007; Revised manuscript received 15 December 2007; Accepted for publication 21 December 2007.
Changes in the Isolated Delayed Component as an Endpoint of Catheter Ablation in Arrhythmogenic Right Ventricular Cardiomyopathy: Predictor for Long-Term Success
Article first published online: 13 FEB 2008
© 2008 Wiley Periodicals, Inc.
Journal of Cardiovascular Electrophysiology
Volume 19, Issue 7, pages 681–688, July 2008
How to Cite
NOGAMI, A., SUGIYASU, A., TADA, H., KUROSAKI, K., SAKAMAKI, M., KOWASE, S., OGINOSAWA, Y., KUBOTA, S., USUI, T. and NAITO, S. (2008), Changes in the Isolated Delayed Component as an Endpoint of Catheter Ablation in Arrhythmogenic Right Ventricular Cardiomyopathy: Predictor for Long-Term Success. Journal of Cardiovascular Electrophysiology, 19: 681–688. doi: 10.1111/j.1540-8167.2008.01104.x
- Issue published online: 25 JUL 2008
- Article first published online: 13 FEB 2008
- arrhythmogenic right ventricular cardiomyopathy;
- delayed component;
- signal-averaged electrocardiography;
- ventricular tachycardia
Introduction: Although successful ablation of ventricular tachycardia (VT) is feasible in arrhythmogenic right ventricular cardiomyopathy (ARVC), long-term recurrence is common. The aim of this study was to assess the usefulness of a change in the isolated delayed component (IDC) as an endpoint of the catheter ablation in ARVC.
Methods and Results: Eighteen patients (48 ± 11 years) with ARVC were studied. Detailed endocardial mapping of the right ventricle (RV) was performed during sinus rhythm. IDCs were recorded in 16 patients and the latest IDCs were related to the VT circuit. Catheter ablation was carried out in the areas with the IDCs. At the end of the session, the IDC was electrically dissociated in one, disappeared in five, exhibited second-degree block in one, was significantly delayed (≥50 ms) in three, and remained unchanged in six. The change in the IDC was correlated with the change in the type II/III late potentials in the signal-averaged electrocardiography (ECG) and the inducibility of the clinical VT after the ablation. During a follow-up of 61 ± 38 months, VT recurred in six. The patients with a changed IDC had a significantly lower VT recurrence than those with no IDC or an unchanged IDC (P < 0.02).
Conclusion: In patients with ARVC, (1) the IDCs during sinus rhythm are related to the clinical VT and can be a target for the ablation, (2) a change in the IDC can be used as an endpoint, and (3) qualitative analyses of the serial signal-averaged ECGs may be useful for the long-term follow-up.