Funding for editorial support was provided by sanofi-aventis US.
Pathophysiology and Disease Progression of Atrial Fibrillation: Importance of Achieving and Maintaining Sinus Rhythm
Article first published online: 26 MAR 2008
© 2008 Wiley Periodicals, Inc.
Journal of Cardiovascular Electrophysiology
Volume 19, Issue 8, pages 885–890, August 2008
How to Cite
COHEN, M. and NACCARELLI, G. V. (2008), Pathophysiology and Disease Progression of Atrial Fibrillation: Importance of Achieving and Maintaining Sinus Rhythm. Journal of Cardiovascular Electrophysiology, 19: 885–890. doi: 10.1111/j.1540-8167.2008.01134.x
Dr. Cohen is a coinvestigator in the CRESCENDO trial and serves on the medical advisory board of sanofi-aventis.
Dr. Naccarelli is an investigator on research grants from sanofi-aventis, Cardiome, ARYX, Wyeth-Ayerst, Boehringer-Ingleheim, and Reliant. He serves on the medical advisory boards of Xantion, Wyeth-Ayerst, Astellas, Cardiome, sanofi-aventis, Reliant, and CV Therapeutics.
Manuscript received 17 December 2007; Accepted for publication 24 December 2007.
Editor: Stephen C. Hammill, M.D.
- Issue published online: 22 JUL 2008
- Article first published online: 26 MAR 2008
- atrial fibrillation;
- antiarrhythmia agents;
- rhythm control;
- ion channels;
- disease progression
Atrial fibrillation (AF) is a progressive disease in which arrhythmia-induced remodeling facilitates evolution from paroxysmal AF to persistent and permanent AF. Changes in electrical, structural, and contractile properties of cardiac tissue that are thought to underlie AF maintenance and progression are reviewed. Also examined is the negative impact of AF on clinical outcomes, as well as the potential benefits of restoration and maintenance of sinus rhythm. Because of the limited efficacy and adverse effects of current antiarrhythmics, new antiarrhythmic drugs need to be developed that provide safer and more effective rhythm control in AF.