Cem Ulucan, M.D. and Vildan Cetintas, M.Sc. contributed equally to the article as first authors.
β1 and β2-Adrenergic Receptor Polymorphisms and Idiopathic Ventricular Arrhythmias
Article first published online: 9 MAY 2008
© 2008 Wiley Periodicals, Inc.
Journal of Cardiovascular Electrophysiology
Volume 19, Issue 10, pages 1053–1058, October 2008
How to Cite
ULUCAN, C., CETINTAS, V., TETIK, A., EROGLU, Z., KAYIKCIOGLU, M., CAN, L. H., PAYZIN, S., AYDIN, M. and HASDEMIR, C. (2008), β1 and β2-Adrenergic Receptor Polymorphisms and Idiopathic Ventricular Arrhythmias. Journal of Cardiovascular Electrophysiology, 19: 1053–1058. doi: 10.1111/j.1540-8167.2008.01202.x
Manuscript received 28 January 2008; Revised manuscript received 3 March 2008; Accepted for publication 12 March 2008.
- Issue published online: 20 SEP 2008
- Article first published online: 9 MAY 2008
- ventricular tachycardia;
- beta adrenergic receptors
Introduction: Idiopathic ventricular arrhythmias commonly refer to ventricular tachycardia (VT) and/or frequent/monomorphic premature ventricular contractions (PVC) in patients with structurally normal heart. Activation of sympathetic tone has been shown to play an important role in the provocation and maintenance of these arrhythmias. We investigated whether common single nucleotide polymorphisms in the β1 and β2-adrenergic receptors are associated with idiopathic ventricular arrhythmias.
Methods: A total of 143 unrelated patients presenting with idiopathic ventricular arrhythmias were prospectively included in a case-control association study. Patient population was matched by age and gender to the unrelated, healthy control subjects (N = 307). All study subjects were of Turkish (Anatolian Caucasian) descent. Allele and genotype frequencies of the Gly389Arg and Ser49Gly polymorphisms of the β1-adrenergic receptor and Arg16Gly, Gln27Glu, and Thr164Ile polymorphisms of the β2-adrenergic receptor were compared between patient population and control subjects. The genotype frequencies were in Hardy-Weinberg equilibrium.
Results: Patients with idiopathic ventricular arrhythmias had higher frequency of Arg389Arg genotype (22.4% vs 1.6%, P < 0.001), Arg389Gly49 (5.24% vs 0.73%, P = 0.005), and Arg389Ser49 (36.7% vs 13.6%, P < 0.001) haplotypes of the β1-adrenergic receptor, and higher frequency of Gly16Gly (31.5% vs 13.4%, P < 0.001), Glu27Glu genotypes (18.2% vs 10.1%, P = 0.006) and Gly16Gln27Thr164 (15.3% vs 7.4%, P = 0.002), Gly16Glu27Thr164 (13.1% vs 7%, P = 0.004), and Gly16Glu27Ile164 (13.2% vs 6%, P = 0.002) haplotypes of the β2-adrenergic receptor compared to control subjects.
Conclusion: Our data suggest that common single nucleotide polymorphisms in the β1 and β2-adrenergic receptors are significantly associated with idiopathic ventricular arrhythmias in Turkish population.