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Keywords:

  • atrial electromechanical coupling;
  • Doppler tissue imaging

Objective: The aim of this study was to evaluate atrial conduction abnormalities obtained by Doppler tissue imaging (DTI) and electrocardiogram analysis in ankylosing spondylitis (AS) patients. Methods: A total of 40 patients with AS (22 males /18 females, 37.82 ± 10.22 years), and 42 controls (22 males/20 females, 35.74 ± 9.98 years) were included. Systolic and diastolic left ventricular (LV) functions were measured by using conventional echocardiography and DTI. Interatrial and intraatrial electromechanical coupling (PA) intervals were measured with DTI. P-wave dispersion (PD) was calculated from the 12-lead electrocardiogram. Results: Atrial electromechanical coupling at the left lateral mitral annulus (PA lateral) was significantly delayed in AS patients (61.65 ± 7.81 vs 53.69 ± 6.75 ms, P < 0.0001). Interatrial (PA lateral – PA tricuspid), intraatrial electromechanical coupling intervals (PA septum – PA tricuspid), maximum P-wave (Pmax) duration, and PD were significantly longer in AS patients (23.50 ± 7.08 vs 14.76 ± 5.69 ms, P < 0.0001; 5.08 ± 5.24 vs 2.12 ± 2.09 ms, P = 0.001; 103.85 ± 6.10 vs 97.52 ± 6.79 ms, P < 0.0001; and 48.65 ± 6.17 vs 40.98 ± 5.37 ms, P < 0.0001, respectively). Reflecting LV diastolic function mitral A-wave and E/A, mitral E-wave deceleration time (DT), Am and Em/Am were significantly different between the groups (P < 0.05). We found a significant correlation between interatrial electromechanical coupling interval with PD (r = 0.536, P < 0.01). Interatrial electromechanical coupling interval was positively correlated with DT (r = 0.422, P < 0.01) and inversely correlated with E/A (r =−0.263, P < 0.05) and Em/Am (r =−0.263, P < 0.05). Conclusion: This study shows that atrial electromechanical coupling intervals and PD are delayed, and LV diastolic functions are impaired in AS patients.